After numerous requests from fellow engineering students with Macs, I created a winebottled version of LTSPice.  This allows you to run LTSpice in OS X without having to boot a Windows VM (via Fusion, Parallels or whatever).  The winebottle includes all the necessary binaries for Wine so it should work out of the box, so to speak.   The first run takes a little bit to set up the environment for Wine, otherwise, subsequent starts should be fairly quick.

*Update (Nov. 2, 2011): I just made a new packaging with a more recent version (v4.12u Oct 6 2011) of LTSpice.  I also used it as a chance to try out Wineskin, instead of the previously used Winebottler.  I’ve only tested it on my laptop (OS X 10.7). If it does/doesn’t work for you with another version of OSX (>=10.5), please let me know in the comments section.  For the time being I’ll keep the older version available.

Winebottled LTSPice for OS X (10.5+): http://irust.in/stuff/LTSPICE_W_WINE.dmg

New! LTSpice v4.12u for OS X (made with Wineskin): LTSpiceIV_v2.dmg

 

related links:

Winebottler: http://winebottler.kronenberg.org/
LTSpice: http://www.linear.com/designtools/software/
Wineskin: http://wineskin.doh123.com/
WineHQ: http://www.winehq.org/